Levofloxacin (Levaquin - a discontinued brand) is a prescription drug used to treat bacterial infections of the sinuses, skin, lungs, ears, airways, bones, and joints. Side effects include nausea, vomiting, diarrhea, headache, and constipation. Read the warnings, drug interactions, dosage, and pregnancy and breastfeeding safety information. Loading dose: 15 mg/kg IV once as a single dose Maintenance dose: 7.5 mg/kg IV or orally every 6 hours Maximum dose: 4 g/day Usual duration of therapy: 7 to 10 days Comments:-Most serious anaerobic infections are treated with IV therapy initially.-Loading and maintenance doses should be infused IV over 1 hour.-The first IV maintenance dose should be started 6 hours after the start of the. -CrCl 20 to 49 mL/min: 500 mg orally or IV once, followed by 250 mg orally or IV every 24 hours-CrCl 10 to 19 mL/min: 500 mg orally or IV once, followed by 250 mg orally or IV every 48 hours When dosage in patients with CrCl at least 50 mL/min is 250 mg every 24 hours:-CrCl 20 to 49 mL/min: No adjustment recommended. For levofloxacin; For oral dosage form (tablets): Adults: 250 to 750 mg once a day for three to twenty-eight days, depending on the medical problem being treated. Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers. For injection dosage form: You should not use Ciloxan if you are allergic to ciprofloxacin or other fluoroquinolones (gemifloxacin, levofloxacin, moxifloxacin, ofloxacin, norfloxacin, and others). Do not use this medicine to treat a viral or fungal infection in the eye. Ciloxan is for use in treating only bacterial infections of the eye. It is not known whether this medicine will harm an unborn baby. Tell your doctor if. Only needs to be taken once a day for most infections. Available as a generic. Cons. Can cause serious side effects. Can make you sunburn easily. Can't be taken at the same time as antacids or certain vitamins. Can affect blood sugar levels if you have diabetes. Pharmacist tips for levofloxacin. Finish all of the levofloxacin your healthcare provider prescribed for you, even if you start to.